Atypical Megakaryocytes in Preleukemic Phase of Acute Myeloid Leukemia

Mono- and binucleated megakaryocytes appeared in the bone marrow of a 6-yr-old white male 9 mo prior to the development of acute myeloid leukemia; in addition, leukopenia and anemia antedated the diagnosis by 3½ and 9 mo, respectively. The report suggests that mono- and binucleated megakaryocytes may be a useful diagnostic finding in early leukemia.