A technique for measuring the refractive index of the cytoplasm of the circulating blood lymphocytes of rabbits is described. This parameter is remarkably constant in normal animals but shows a significant rise following the application of skin homografts, but not of skin autographs, in rabbits. The rise in refractive index reaches or exceeds the extreme normal range between the third and fifth day after application of the graft, with rejection coming on the tenth day. It is suggested that this technique is worth further investigation as a possible early predictor of graft rejection.

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© 1972 by American Society of Hematology, Inc.
1972
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