Monoclonal Gammopathy in a Child with Leukemia

This paper describes the case history of a boy found to suffer from acute blastic leukemia at the age of two years. Manifestations of an intracranial localization of the leukemic process occurred several times in the course of the next 18 months; a generalized relapse responded well to therapy.

The boy subsequently developed a severe refractory virus infection of the skin and suffered a few other virus infections, without any of the usual changes in the morphology of the blood. A few weeks later he developed a monoclonal gammopathy of the IgG class type L with Bence Jones proteinuria, likewise of type L.

The possible causes of this clinical course and of the paraproteinemia are discussed.