Brief Report: Erythropoiesis after Exchange Transfusion in Hemolytic Anemia

Exchange transfusion with preservation of a constant hemoglobin concentration in three patients with hereditary spherocytosis, and one patient with acquired hemolytic anemia did not result in any significant change in the rate of red cell production as measured by serum iron turnover and bone marrow examinations. These observations support the hypothesis that tissue hypoxia controls red cell production.