Abstract
In addition to genetic alterations, epigenetic events have been recently proposed to play a role in the pathogenesis and progression of various malignancies. We wanted to study the role of both global genetic and epigenetic changes during leukemic progression by combining Whole genome methylation, Gene expression and DNA copy number alteration analyses. We used a cell line model of LGL derived from the same patient at two different stages of disease (
Daibata, Int J Cancer
.2004
;108
(6):845
Author notes
Disclosure: No relevant conflicts of interest to declare.
2007, The American Society of Hematology
2007