Abstract
KCl Cotransport (KCC) is active in normal (AA) reticulocytes and overly active in sickle (SS) reticulocytes. Cell swelling activates KCC and induces a powerful regulatory volume decrease (RVD) in reticulocytes, which increases cellular hemoglobin concentration (CHC) to new steady state values that are higher in SS than AA cells (
Blood
2004
;104
(9):2954
–60Blood
2004
; 104
(11): 976a
Topics:
erythrocytes,
potassium chloride,
urea,
biotin,
cations,
edema,
glucose,
hemoglobin,
hepes,
nystatin
Author notes
Corresponding author
2005, The American Society of Hematology
2005