Abstract
We recently demonstrated that the activity of the PMCA varies greatly among the RBCs in a normal blood sample (Lew et al.,
Blood
102
:4206
,2003
Gonzalez Flecha et al.,
) or to other mechanisms, remains to be determined. The age-decline in PMCA activity may be responsible for the increasing density of aging RBCs, by allowing intermittent episodes of [Ca2+]i elevations in the circulation, with transient Gardos channel activation and gradual dehydration by net KCl and water loss.J Membr Biol
171
:25
,1999
Author notes
Corresponding author
2005, The American Society of Hematology
2005