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Journal Articles

Platelet spleen tyrosine kinase is a key regulator of anti-PF4 antibody–induced immunothrombosis

Jan Zlamal, Vera M. Ripoll, Christine S.M. Lee, Filip Toma, Karina Althaus, Flavianna Rigoni, Andreas Witzemann, Shane Whittaker, David Capraro, Günalp Uzun, Tamam Bakchoul, Vivien M. Chen
Journal: Blood Advances
Blood Adv (2025) 9 (8): 1772–1785.
https://doi.org/10.1182/bloodadvances.2024014167
Published: 2025
Includes: Supplemental data
Journal Articles

Unraveling antibody-induced structural dynamics in the ADAMTS13 CUB1-2 domains via HDX-MS

Quintijn Bonnez, Emily R. Legan, Inge Pareyn, Febe Boudry, Jennifer Anckaert, Claudia Tersteeg, Simon F. De Meyer, Renhao Li, Karen Vanhoorelbeke
Journal: Blood Advances
Blood Adv (2025) 9 (8): 1763–1771.
https://doi.org/10.1182/bloodadvances.2024014950
Published: 2025
Includes: Supplemental data
Journal Articles

A model of zymogen factor XII: insights into protease activation

Aleksandr Shamanaev, Yujie Ma, Michal B. Ponczek, Mao-fu Sun, Quifang Cheng, S. Kent Dickeson, Owen J. T. McCarty, Jonas Emsley, Bassem M. Mohammed, David Gailani
Journal: Blood Advances
Blood Adv (2025) 9 (8): 1940–1951.
https://doi.org/10.1182/bloodadvances.2025015842
Published: 2025
Includes: Supplemental data
Journal Articles

Red blood cell aggregation within a blood clot causes platelet-independent clot shrinkage

Alina D Peshkova, Ekaterina K Rednikova, Rafael R Khismatullin, Oleg V. Kim, Vladimir R Muzykantov, Prashant K Purohit, Rustem I Litvinov, John W. Weisel
Journal: Blood Advances
Blood Adv bloodadvances.2024015533.
https://doi.org/10.1182/bloodadvances.2024015533
Published: 2025
Includes: Supplemental data
Journal Articles

Recurrent Thrombosis and Major Bleeding in Children Treated for VTE

Stephanie F Lenahan, Anne Blackmore, Matthew Fenchel, Evan Thomas, Joseph S. Palumbo, Cristina Tarango
Journal: Blood Advances
Blood Adv bloodadvances.2025016135.
https://doi.org/10.1182/bloodadvances.2025016135
Published: 2025
Journal Articles

Patient anti-FVIII drug antibodies bind preferentially to a subset of FVIII covalent states

Diego Butera, Aster E Pijning, Nathan G Avery, Carmen Helena Coxon, Clive Metcalfe, Angelina Mimoun, Sebastien Lacroix-Desmazes, Paul Clinton Spiegel, Jr, Philip J Hogg
Journal: Blood Advances
Blood Adv bloodadvances.2025016474.
https://doi.org/10.1182/bloodadvances.2025016474
Published: 2025
Includes: Supplemental data
Journal Articles

Duration of primary/secondary treatment to prevent recurrent venous thromboembolism: a systematic review and meta-analysis

Anqi Li, Rasha Khatib, Luciane Cruz Lopes, Fazila Aloweni, Liming Lu, Qingyong He, Jiaming Wu, Peiming Zhang, Yuyuan Tang, Sureka Pavalagantharajah, Nigar Sekercioglu, Carlos A. Cuello Garcia, Serge Koujanian, Arnav Agarwal, Sean Alexander Kennedy, Ignacio Neumann, Sam Schulman, Wojtek Wiercioch, Gabriel Rada, Andrew M. Peseski, Thomas L. Ortel, Yu-Qing Zhang
Journal: Blood Advances
Blood Adv (2025) 9 (7): 1742–1761.
https://doi.org/10.1182/bloodadvances.2024015371
Published: 2025
Includes: Supplemental data
Journal Articles

N-glycan shielded CUB domains of ADAMTS13 prevent binding of C-terminal antibodies in patients with immune-mediated TTP

Tim Postmus, Nelly Schilder, Juliana Ferreira de Santana, Pieter Langerhorst, Paul Kaijen, Paul Coppo, Bérangère S. Joly, Agnès Veyradier, Karen Vanhoorelbeke, Jan Voorberg
Journal: Blood Advances
Blood Adv (2025) 9 (7): 1728–1737.
https://doi.org/10.1182/bloodadvances.2024014298
Published: 2025
Includes: Supplemental data
Journal Articles

Agents of shield: glycans mask antibody epitopes on ADAMTS13

Colin A. Kretz
Journal: Blood Advances
Blood Adv (2025) 9 (7): 1726–1727.
https://doi.org/10.1182/bloodadvances.2025015862
Published: 2025
Journal Articles

Discrepancy between original and adapted ASH VTE guidelines: same clinical evidence but different recommendations.

Suely Meireles Rezende, Ignacio Neumann, Benjamin Djulbegovic
Journal: Blood Advances
Blood Adv bloodadvances.2025016102.
https://doi.org/10.1182/bloodadvances.2025016102
Published: 2025
Includes: Supplemental data
Journal Articles

Platelet activating histone/antihistone IgG complexes in anti-PF4 negative thrombosis and thrombocytopenia syndrome.

Max Esefeld, Stefan Handtke, Rainer Kaiser, Leo Nicolai, Lea Di Fina, Dario Rossaro, Jan Wesche, Justina Rath, Ann-Christin Wienrich, Till Hoffmann, Lukas Harasser, Clemens Feistritzer, Lorin Loacker, Kourosh Lotfi, Margareta Holmström, Jovan Antovic, Leif Steil, Uwe Volker, Lena Ulm, Karsten Becker, Nils-Olaf Hübner, Andreas Greinacher, Thomas Thiele
Journal: Blood Advances
Blood Adv bloodadvances.2024015076.
https://doi.org/10.1182/bloodadvances.2024015076
Published: 2025
Includes: Supplemental data
Journal Articles

American Society of Hematology living guidelines on use of anticoagulation for thromboprophylaxis for patients with COVID-19: executive summary

Deborah M. Siegal, Eric K. Tseng, Holger J. Schünemann, Pantep Angchaisuksiri, Adam Cuker, Kathryn Dane, Maria T. DeSancho, David Diuguid, Daniel O. Griffin, Frederikus A. Klok, Alfred Ian Lee, Ignacio Neumann, Ashok Pai, Marc Righini, Kristen M. Sanfilippo, Deirdra R. Terrell, Elie A. Akl, Reyad Al Jabiri, Yazan Al Jabiri, Angela M. Barbara, Antonio Bognanni, Imad Bou Akl, Mary Boulos, Romina Brignardello-Petersen, Matthew Chan, Rana Charide, Luis E. Colunga-Lozano, Karin Dearness, Andrea J. Darzi, Heba Hussein, Samer G. Karam, Philipp Kolb, Razan Mansour, Gian Paolo Morgano, Rami Z. Morsi, Giovanna Muti-Schünemann, Menatalla K. Nadim, Atefeh Noori, Binu A. Philip, Thomas Piggott, Yuan Qiu, Yetiani Roldan Benitez, Finn Schünemann, Adrienne Stevens, Karla Solo, Wojtek Wiercioch, Reem A. Mustafa, Robby Nieuwlaat
Journal: Blood Advances
Blood Adv (2025) 9 (6): 1247–1260.
https://doi.org/10.1182/bloodadvances.2024014219
Published: 2025
Includes: Supplemental data
Journal Articles

Development of a protease-resistant ADAMTS13 to improve stability against proteolytic degradation

Veronica DeYoung, Rex Huang, Hasam Madarati, Rida Malik, Peter Anthony Andrisani, Cherie Teney, Colin A. Kretz
Journal: Blood Advances
Blood Adv bloodadvances.2024015212.
https://doi.org/10.1182/bloodadvances.2024015212
Published: 2025
Includes: Supplemental data
Journal Articles

Venous Thrombosis Unchained: Pandora's Box of Non-Inflammatory Mechanisms

Sophie Robyn Megan Smith, Neil V. Morgan, Alexander Brill
Journal: Blood Advances
Blood Adv bloodadvances.2024014114.
https://doi.org/10.1182/bloodadvances.2024014114
Published: 2025
Journal Articles

Validation of Risk Assessment Models for Venous Thromboembolism in Cancer Patients Receiving Systemic Therapies

Nikola Vladić, Cornelia Englisch, Julia Maria Berger, Florian Moik, Anna Sophie Berghoff, Matthias Preusser, Ingrid Pabinger, Cihan Ay
Journal: Blood Advances
Blood Adv bloodadvances.2025016044.
https://doi.org/10.1182/bloodadvances.2025016044
Published: 2025
Includes: Supplemental data
Journal Articles

Cooperative effect between anti-PF4/H and anti-PF4 antibodies increases cell activation and thrombotic risk in HIT

Sandra Billy, Caroline Vayne, Ophélie Bertin, Elodie Miquelestorena-Standley, Noémie Charuel, Annabelle Dupont, Loïs Coënon, Claire Pouplard, Yotis A Senis, Yves Gruel, Jerome Rollin
Journal: Blood Advances
Blood Adv bloodadvances.2024015095.
https://doi.org/10.1182/bloodadvances.2024015095
Published: 2025
Includes: Supplemental data
Journal Articles

VWF-ADAMTS13 imbalance bridges infection to stroke

Jing-fei Dong, Cha Han
Journal: Blood Advances
Blood Adv (2025) 9 (6): 1342–1343.
https://doi.org/10.1182/bloodadvances.2024015665
Published: 2025
Journal Articles

The preclinical profile of SerpinPC- a potential new treatment for hemophilia

James A. Huntington, Jill Reckless, Stéphanie G.I. Polderdijk, Patrick Hextall, Trevor Baglin
Journal: Blood Advances
Blood Adv bloodadvances.2024015201.
https://doi.org/10.1182/bloodadvances.2024015201
Published: 2025
Includes: Supplemental data
Journal Articles

Untangling profiles of post-thrombotic syndrome using unsupervised machine learning

Aaron F.J. Iding, Vincent ten Cate, Hugo ten Cate, Philipp S. Wild, Arina J. ten Cate-Hoek
Journal: Blood Advances
Blood Adv bloodadvances.2025015829.
https://doi.org/10.1182/bloodadvances.2025015829
Published: 2025
Includes: Supplemental data
Journal Articles

Loss of factor VIII in zebrafish rebalances antithrombin deficiency but has a limited bleeding diathesis

Raghunath Azhwar, Catherine E. Richter, Megan S Griffin, Sylvia M Emly, Murat Yaman, Valder R Arruda, Benjamin J Samelson-Jones, Jordan A Shavit
Journal: Blood Advances
Blood Adv bloodadvances.2024013143.
https://doi.org/10.1182/bloodadvances.2024013143
Published: 2025
Includes: Supplemental data