The 2019 ASH guidelines for immune thrombocytopenia (ITP) included recommendations on management of adults (recommendations 1-9) and children (recommendations 10-21) with primary ITP (1). We describe here results of a review of the 2019 guidelines by a working group of experts requested by ASH to inform decision-making about the need for and timing of a guideline revision. An updated Medline and Embase search applied the same search terms as in the 2019 ASH guidelines, limited to systematic reviews and clinical trials, from May 2017 to July 2022. There were 193 studies identified, 102 underwent abstract review and 54 full review. Each study was assessed based on relevance to the previous recommendation with regards to the population, prioritized outcomes, new outcomes, and study design. Reviewers assessed if the data would change the strength or the directionality of the existing recommendation or merit development of a new recommendation. Based on this review, the ASH Committee on Quality endorsed a focused update on second-line management for adults with ITP. In addition, there will be continued annual monitoring and reviewing of the 2019 ASH guidelines on ITP in full to evaluate when there is sufficient new evidence to warrant additional revisions.
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Review Article|
April 12, 2024
2022 Review of the 2019 American Society of Hematology Guidelines on Immune Thrombocytopenia
Cindy E. Neunert,
Columbia University Irving Medical Center, New York, New York, United States
* Corresponding Author; email: cn2401@cumc.columbia.edu
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Donald M. Arnold,
Donald M. Arnold
Department of Medicine, Michael G. DeGroote Centre for Transfusion Research, McMaster University, Canada
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Rachael F. Grace,
Rachael F. Grace
Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, United States
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Thomas Kühne,
Thomas Kühne
University Children's Hospital Basel, Basel, Switzerland
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Keith R McCrae,
Keith R McCrae
Cleveland Clinic, Cleveland, Ohio, United States
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Deirdra R Terrell
Deirdra R Terrell
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
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Blood Adv bloodadvances.2023012541.
Article history
Submitted:
January 18, 2024
Revision Received:
March 11, 2024
Accepted:
March 26, 2024
Citation
Cindy E. Neunert, Donald M. Arnold, Rachael F. Grace, Thomas Kühne, Keith R McCrae, Deirdra R Terrell; 2022 Review of the 2019 American Society of Hematology Guidelines on Immune Thrombocytopenia. Blood Adv 2024; bloodadvances.2023012541. doi: https://doi.org/10.1182/bloodadvances.2023012541
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