Subjects:
Evidence-Based Minireview
Learning Objectives
Describe the burden of bone disease and bone pain in SCD
Summarize the available evidence, including the efficacy and safety of bisphosphonates, in SCD
J.D., a 12-year-old boy with hemoglobin sickle cell disease (Hb SCD) and infrequent vaso-occlusive episodes (VOEs) in childhood, developed excruciating, atypical pain in his thighs after resolution of an uncomplicated VOE. Opioids, nonsteroidal anti-inflammatory drugs, gabapentin, antidepressants, and muscle relaxants did not alleviate his lower-extremity pain. X-rays, magnetic resonance imaging, and computed tomographic scans of his lower extremities were unrevealing. Physical, occupational, and alternative therapies such as acupuncture offered minimal relief. Over the next 5 years, J.D. became increasingly withdrawn as his chronic pain and debility negatively impacted his school attendance and peer relationships. At age 17 years (weight, 51.4 kg; height, 1.7 m; body mass index, 17.1 kg/m2), he underwent his...
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.Copyright © 2024 by The American Society of Hematology
2024
Copyright © 2024 by The American Society of Hematology
2024
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