Review the available data regarding choice and duration of anticoagulation to prevent recurrent thrombosis in polycythemia vera
Discuss the available data regarding cytoreductive agents and their efficacy for secondary thrombosis prevention in polycythemia vera
A 50-year-old woman develops a right femoral deep vein thrombosis. Laboratory results reveal a hemoglobin of 17 g/dL, hematocrit of 50%, platelet count 560 K/µL, and erythropoietin level of 1.5 IU/L. Molecular testing reveals a JAK2 V617F mutation with a variant allele frequency (VAF) of 60%. Additional hypercoagulable workup is negative.
Polycythemia vera (PV), one of the myeloproliferative neoplasms (MPNs), is a clonal hematologic malignancy characterized by activating mutations in JAK2. Approximately 95% of patients with PV have mutations in either Janus kinase 2 (JAK2) V617F or exon 12 resulting in excess erythropoiesis, increased red blood cell mass, and aberrant cytokine...