Learning Objectives

  • Recognize common barriers limiting access to cellular therapies for patients with large B-cell lymphoma

  • Explore strategies for improving access to cellular therapy among patients treated in community settings

A 56-year-old Hispanic male without health insurance coverage was diagnosed with stage IV nonbulky diffuse large B-cell lymphoma, not otherwise specified (MYC, BCL2, BCL6 nonrearranged; Ki-67 70%). He received county health coverage and initial treatment at a local county hospital. Treatment with R-CHOP initially achieved complete response (CR), but unfortunately the lymphoma relapsed with bulky adenopathy. His cancer care system does not perform cellular therapies, but he is motivated to get the best available treatment.

Prior to 2022, the standard of care (SOC) approach for patients with relapsed or refractory large B-cell lymphoma (LBCL) consisted of salvage immunochemotherapy to achieve response followed by consolidation with high-dose therapy and autologous hematopoietic...

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