Review the major updates in the 2023 American College of Rheumatology and European Alliance of Associations for Rheumatology classification criteria for APS
Understand the distinction between classification criteria used for research purposes versus clinical care
A 43-year-old woman is evaluated for thrombocytopenia, with a nadir platelet count of 50 × 109/L. Three months prior, she was found to have mitral valve thickening on an echocardiogram performed for shortness of breath. A lupus anticoagulant is persistently positive at baseline and 12 weeks later. An alternative etiology for thrombocytopenia is not identified. Does this patient meet classification criteria for antiphospholipid syndrome?
Antiphospholipid syndrome (APS) is an acquired systemic autoimmune disorder characterized by macrovascular arterial or venous thrombosis, pregnancy morbidity, microvascular phenomena, and other nonthrombotic manifestations in the context of compatible laboratory testing for antiphospholipid antibodies (aPL). An APS...