American Society of Hematology

Figure 1.

Allelic association with responder status. (A) Loci on chromosomes 2 and 5 have SNPs close to genome-wide significance (red line, P = 5.0 × 10−8). Genomic inflation factor (based on median χ2) is 1.013. (B) LocusZoom plot of imputed chromosome 2 region. SNP rs66516066 reaches genome-wide significance. A SNP cluster in strong LD is 0.5 Mb downstream of NBAS. (C) LocusZoom plot of imputed chromosome 5 region. rs7585387 SNP cluster is located with long noncoding RNA gene LOC101927766 and 0.7 Mb upstream of ADRA1B. Purple highlighted region between peaks of increase recombination rate indicates the location of identified rare haplotype.

Allelic association with responder status. (A) Loci on chromosomes 2 and 5 have SNPs close to genome-wide significance (red line, P = 5.0 × 10⁻⁸). Genomic inflation factor (based on median χ²) is 1.013. (B) LocusZoom plot of imputed chromosome 2 region. SNP rs66516066 reaches genome-wide significance. A SNP cluster in strong LD is 0.5 Mb downstream of NBAS. (C) LocusZoom plot of imputed chromosome 5 region. rs7585387 SNP cluster is located with long noncoding RNA gene LOC101927766 and 0.7 Mb upstream of ADRA1B. Purple highlighted region between peaks of increase recombination rate indicates the location of identified rare haplotype.

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