Inhibition of EZH2 and Bcl-2 in combination results in tumor reduction and prolonged survival in vivo. (A,D,G) Tumor volume over time in SUDHL-6 xenografts and PDXs, as measured by calipers. Error bars represent standard error of the mean (SEM). Tumor growth in SUDHL-6 (B) and PDX (E) xeongrafts, as measured by area under the curve (AUC), for the duration of treatment. Error bars represent SEM. (C,H) Kaplan-Meier curve for overall survival. P values represent comparison with combination therapy for each cohort. Among PDX mice treated with combination therapy, 2 deaths occurred, both in mice without tumors. (F) MRI 3D renderings of PDX mice taken at day 19 and at day 92. Images were obtained using a 1T M3 compact MRI system (Aspect Imaging Ltd.) with a T2-weighted scan without contrast. The tumor area of interest, as determined by automatic thresholding settings, is shown in red. ***P < .001, ****P < .0001.