Genomic data from patient specimens at time of clinical trial enrollment. (A) Genomic profile of somatic mutations in baseline samples, as detected by next-generation sequencing data. Each column represents a patient (n = 24) and each row in the top panel represents a gene that carries at least 1 pathogenic or likely pathogenic mutation (n = 38). The upper bar plot indicates the number of somatic mutation(s) per patient, colored according to the type of the alteration, as described in the legend. The right bar plot shows the number of somatic mutations per gene. The frequency of mutations in the cohort is listed on the left border of the figure. The clinical response to treatment is displayed in the annotation bar at the lower axis of the figure according to the legend. (B) Distribution of mutations across all genes in the cohort. The bars are colored according to the proportion of patient’s response to the treatment. Color code: complete remission with incomplete hematologic recovery (blue); partial response (orange); no response (NR; red); response not evaluable (N/E; gray).