FVIII:C PK (median, IQR and range) in severe VWD patients after rVWF infusion. Median, IQR, and range of FVIII:C (U/dL) over 96 hours in severe VWD patients (N = 16) in a nonbleeding state. (A) rVWF (50 IU VWF:RCo/kg) administered together with rFVIII (38.5 IU/kg). (B) rVWF alone (50 IU VWF:RCo/kg).