One-way sensitivity analysis. All model parameters were varied across the ranges indicated in Tables 1-3 to determine changes in the ICER of first-line ibrutinib. Only model parameters that produced a >$5000 per QALY change when evaluated across their entire range are included in the tornado diagram. *, Dominated. ☆, ICER exceeds $5 million per QALY. Blue bars represent the lower value in the range; red bars represent the higher value. 1L, first-line; 2L, second-line; BSC, best supportive care.