Clinical implications of clearance of MRD from all patients and adjusted for standard-risk patients after EOI2 by 5-year DFS and OS. Five-year OS based on the clearance of MRD at EOI1 and EOI2 of all 523 patients with data at both time points (A) and adjusted for those with standard risk (N = 225) (B) are shown. Five-year DFS based on the clearance of MRD at EOI1 and EOI2 of all 523 patients with data at both time points (C) and adjusted for those with standard risk (N = 225) (D) are shown.