Clinical relevance of genomic and epigenomic alterations in MCL subtypes. (A) Impact of driver alterations on OS. The impact is quantified with the 95% confidence interval of the log hazard ratios. The Q value shown is the adjusted P value of the log-rank test. Only alterations with at least 3 altered cases and prognostic value are shown. Drivers with independent prognostic value (Q < 0.05) of the number of CNA are indicated (*). (B) Impact of the cumulative number of genetic and epigenetic changes to OS. The impact is quantified with the 95% CI of the log hazard ratios. Continuous variables were scaled. The Q value shown is the adjusted P value of the simple Cox regression for the continuous variables or the log-rank test for the binary variables (BFB and chromothripsis). The number of SV was available in 42 cases. The epiCMIT was available in 51 cases and its effect was adjusted by the cell of origin (C1/C2). (C) Kaplan-Meier curves of OS according to the number of risk features (high CNA, high epiCMIT, and/or presence of BFB). Number of CNA >7 (median) and epiCMIT >0.6 (valley of a bimodal distribution) were considered high. no. alt, number of altered cases.