Figure 6.
The effect of EPO is modulated by the iron-restrictive properties of Tmprss6-ASO. In Hbbth3/+ animals, administration of Tmprss6-ASO induced reduction of the total amount of splenic proerythroblasts positive for the phosphorylated form of Akt (A) and Jak2 (B) when normalized to the total amount of EPO in circulation. The total number of splenic CFU-Es (expressed in Abs#). followed a similar profile (C). Bars represent SD. Asterisks refer to statistically significant differences (***P ≤ .005, **P ≤ .01; *P ≤ .05).

The effect of EPO is modulated by the iron-restrictive properties of Tmprss6-ASO. In Hbbth3/+ animals, administration of Tmprss6-ASO induced reduction of the total amount of splenic proerythroblasts positive for the phosphorylated form of Akt (A) and Jak2 (B) when normalized to the total amount of EPO in circulation. The total number of splenic CFU-Es (expressed in Abs#). followed a similar profile (C). Bars represent SD. Asterisks refer to statistically significant differences (***P ≤ .005, **P ≤ .01; *P ≤ .05).

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