![As Red Cells Become Oxygenated in the Lungs, a Nitric Oxide (NO) Group is Covalently Bound to the Highly Conserved Cys93 Residue in the ß-Chain of Hemoglobin. In this high oxygen affinity state (the relaxed, R-state), SNO-Hgb is unreactive, but upon Hgb deoxygenation in the periphery and the consequent transition to the low oxygen affinity state (the tense, T-state), SNO-Hgb can react with red cell thiols (e.g., glutathione [GSH] or anion exchanger-1 [AE-1]) via transnitrosation and thereby transmit a vasodilatory signal (RSNO) out of the red cell.](https://ash.silverchair-cdn.com/ash/content_public/journal/thehematologist/6/1/10.1182_hem.v6.1.6175/2/6175a.jpeg?Expires=1724246708&Signature=rwgIWyMqADH-SZEVpBGAAyred6ap3TuXgLsIFEcGVl9nOPtJZqjcYdf3~qLAufenzSP4lMnegj6SybfnnYamVg0-ABiCyMRbeUrRErUiHD5WpCqG07~GoqvB7XtXB5LUeXJJmXzkSwjMbl7JlxhuzkOLpG7rzJWYhcAc7WcbHmNK-XOjr~qN9m0wTZ0R5KR8smX8iRPl2S97HCG7eoFGczlVoZZx5yu-fNCjaRw2Zrs90eNTjdMUu7DoWHSIVM-LumLKRfGcwLLpBrsVW8qFqpjL0nmZdOXjJiO~4r5fgnhAx9rN-Fw8YoqK0CdpVTDQKg0qDSrUNTrhyOgHz5v4nw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
As Red Cells Become Oxygenated in the Lungs, a Nitric Oxide (NO) Group is Covalently Bound to the Highly Conserved Cys93 Residue in the ß-Chain of Hemoglobin. In this high oxygen affinity state (the relaxed, R-state), SNO-Hgb is unreactive, but upon Hgb deoxygenation in the periphery and the consequent transition to the low oxygen affinity state (the tense, T-state), SNO-Hgb can react with red cell thiols (e.g., glutathione [GSH] or anion exchanger-1 [AE-1]) via transnitrosation and thereby transmit a vasodilatory signal (RSNO) out of the red cell.
