(A) Schematic of common changes acquired in the differentiation and progression of chronic myeloid neoplasms (adapted from McClure RF et al. J Mol Diagn. 2018;20:717-737). (B) Lumpers: comparison of the NMNs with myeloproliferative neoplasms (MPNs), myelodysplastic syndromes (MDS), and age-related clonal hematopoiesis (adapted from Zhang H et al. Blood. 2019;134:867-879). (C) Splitters: comparison between the NMNs (diagram derived from Meggendorfer M et al. Haematologica. 2018 May;103:e192-e195). CNL, chronic myeloid neoplasms; aCML, atypical chronic myeloid leukemia; CMML, chronic myelomonocytic leukemia; CNL, chronic neutrophilic leukemia; ET, essential thrombocythemia; MF, myelofibrosis; MPN-RS-T, MPN with ring sideroblasts and thrombocytosis; MPN-U, unclassifiable MPN; PV, polycythemia vera; SM, systemic mastocytosis.