Percentage survival of NSG mice injected with primary human FLT3-ITD+ acute myeloid leukemia (AML) cells derived from an HLA-A2+ patient with or without additional allogeneic human CD8+ T cells that had been stimulated and expanded in the presence of autologous dendritic cells expressing allogeneic HLA-A2 upon RNA transfection in vitro. Mice were treated with vehicle or sorafenib as indicated. The experiment was performed twice with similar results; n values represent biologically independent mice. p values were calculated using the two-sided Mantel-Cox test.

Percentage survival of NSG mice injected with primary human FLT3-ITD+ acute myeloid leukemia (AML) cells derived from an HLA-A2+ patient with or without additional allogeneic human CD8+ T cells that had been stimulated and expanded in the presence of autologous dendritic cells expressing allogeneic HLA-A2 upon RNA transfection in vitro. Mice were treated with vehicle or sorafenib as indicated. The experiment was performed twice with similar results; n values represent biologically independent mice. p values were calculated using the two-sided Mantel-Cox test.

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