Progression-free and Overall Survival Curves. Kaplan-Meier curves for progression free survival (n = 429) A) and overall survival (n = 1,347) B) of patients with type 1 mutations (group I), with type 2 but not type 1 mutations (group II), with SF3B1 but no type 1 or type 2 mutations (group III), and other patients with no type 1, type 2 or SF3B1 mutations (group IV). Reprinted by permission from Macmillan Publishers Ltd: Nature Genetics doi:10.1038/ng.3742, copyright 2016.