![B-cell activation (eg, via B-cell receptor [BCR] and CD40 engagement) induces the expression of dual-specificity phosphatase (DUSP4), which negatively regulates c-JUN N-terminal kinase (JNK) 1/2 by dephosphorylation, resulting in apoptosis. Inhibition of BTK and JNK1/2 acts synergistically to promote apoptosis of lymphoma cells.© Rickert R., 2015. Originally published in J Exp Med. doi:10.1084/ jem.2125insight2.](https://ash.silverchair-cdn.com/ash/content_public/journal/thehematologist/12/5/10.1182_hem.v12.5.4320/2/3dc2dc35-420f-469e-8b60-b33aa4d9177e.jpeg?Expires=1724239604&Signature=HxHtQYmpEUQ1Rq9mWZaRR8YYNzeJrcrzWoM1UiUOSV2UGlyumNB07xE9uB4xbrjnnqaKU28QIAllDHhZ9fHcR0mL0yktRZuTDA2XWGTwRd67k4YMGRzRlMUcVrU1-5dGQCMncTlif4BEPh3VMYPxZkEXZNEU5pFU7Teu1eo7bVS3IN2CSeyTgf1-t54Q2vCFBABuJrnTlt3gc-Q8M4I-j0zpe95hdGfm8cG3MrF7Rkad9puz67jvIt~EMMELfnFIQkLCCe4ZLsuIjajEONEgDmw91opo3OOZsqPqppbBE0KM81zrH-NkybmRWMWIEgs661FEXcHQUCSjlTh7dRVY1Q__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
B-cell activation (eg, via B-cell receptor [BCR] and CD40 engagement) induces the expression of dual-specificity phosphatase (DUSP4), which negatively regulates c-JUN N-terminal kinase (JNK) 1/2 by dephosphorylation, resulting in apoptosis. Inhibition of BTK and JNK1/2 acts synergistically to promote apoptosis of lymphoma cells.© Rickert R., 2015. Originally published in J Exp Med. doi:10.1084/ jem.2125insight2.
