Silent Cerebral Infarction (SCI). A small stroke is visualized here in T2-weighted (panel A) and diffusion-weighted magnetic resonance images (panel B) in a patient with sickle cell disease. Given the restricted diffusion (panel B), this stroke was imaged in the acute phase (onset in the past 10 to 14 days). This patient with incidentally discovered acute silent cerebral ischemia was asymptomatic, had a normal neurologic examination, was in his baseline state (“steady-state”), and was undergoing a screening MRI for a clinical trial. The motor strip was not affected by this stroke, so it is classified as “silent” (an SCI), but a stroke is a stroke, and the brain is more than a motor strip.