Lamin-A Relative to B-Type Lamins, Transformed to a Measurable A:B Ratio Versus Calibrated Sum Intensity A+B. Log-log plot of intensity of nuclear lamins A + B versus ratio of lamin-A:lamin-B in human bone marrow and peripheral blood cells based on mean fluorescence intensity of A-type lamins and B-type lamins as quantified by mass spectrometrycalibrated intracellular flow cytometry. The dashed line demarcates cells residing in bone marrow (BM) in upper gray area and cells circulating in the peripheral blood (PB) in lower pink area. Abbreviations: CD34+,CD38- , cell population enriched in hematopoietic stem cells; CD34+,CD38+, cell population enriched in multipotent hematopoietic progenitors with limited proliferative capacity; MSC, mesenchymal stromal cells; MkP, megakaryocyte progenitors; MK, megakaryocytes; ProEry, proerythroblasts; lateEry, late-stage erythroblasts; BM-G and BM-M, bone marrow granulocytic and monocytic cells; PB GM, peripheral blood granulocytes and monocytes; T, T-lymphocytes; B, B-lymphocytes; RBC, erythrocytes; Plt, platelets.Shin J et al. Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells. PNAS. 2013;110:18893.