The number of CD8 and CCR7⁺CD45RA⁺T cells commensurate with TB is critical to achieving durable response after axi-cel. (A-F) Logistic regression analysis of response (right) and durable response (middle) and quartile analysis of peak CAR T-cell levels and peak CAR T-cell levels normalized to TB (left) by the number of CD8 T cells (A-C) or the number of CD8 T cells normalized to TB (D-F). (G) The number of CD8 T cells among patients with low TB (below median, left) and high TB (above median, right) by response. (H-P) Logistic regression analysis of response (right), durable response (middle), and quartile analysis of peak CAR T-cell levels and peak CAR T-cell levels normalized to TB (left) by the number of CCR7⁺CD45RA⁺ T cells (H-J), the number of CCR7⁺CD45RA⁺ T cells normalized to TB (K-M), or CD4:CD8 ratio (N-P). P values were calculated using Kruskal-Wallis and Dunn’s tests for box plots. Spearman’s correlation was used to calculate R and P values for bar graphs.