Adaptive immune responses are not required for the decrease in leukemia burden following myeloid depletion. (A) Schematic diagram depicting the dosing schedule for clodlip treatment to deplete myeloid cells in Rag2^−/− mice transplanted with primary LN3 T-ALL. Quantification of the number of splenic T-ALL cells (B) and weight of spleens (C) from T-ALL–bearing Rag2^−/− mice in the indicated treatment groups. Bars represent means + standard error of the mean of data compiled from 3 independent experiments, each with a distinct color-coded primary T-ALL; circles represent individual mice. **P < .01, ***P < .001, unpaired Student t test.