Myeloid inflammation–associated pathways are upregulated with long-term treatment. PBMCs at baseline (B; n = 10), week 4 (W4; n = 11), week 16 (W16; n = 11), and week 56 (W56; n = 12) plus age-matched healthy controls (n = 9) were analyzed using NanoString Myeloid Inflammation Panel. (A) Pathway signature scores determined using NanoString Advanced Analysis Module. (B) Expression of genes at all time points analyzed that showed a statistically significant (P < .05) change in expression between B and W56 listed from most to least significant. (C) Expression profile of S100A11 and CTSS. P values from a Kruskal-Wallis test Dunn’s multiple comparisons to B. ***P < .001.