Changes in immune profile assessed using NanoString Immune Profiling Panel shows significant upregulation of myeloid genes and pathways. (A) Pathway signature scores determined using NanoString Advanced Analysis Module at baseline (B; n = 8), week 4 (W4; n = 12), week 16 (W16; n = 10), and week 56 (W56; n = 10). (B) Expression of genes at all time points analyzed that showed a statistically significant (P < .05) change in expression between B and W56 listed from most to least significant. (C) Macrophage cell score determined using NanoString Advanced Analysis Module at B (n = 8), W4 (n = 12), W16 (n = 10), and W56 (n = 10). P values from a Kruskal-Wallis test with Dunn’s multiple comparisons. ***P < .001.