Functional capacity but not TCR repertoire changes in T cells with long-term treatment. (A-B) TCRβ repertoire was measured at baseline and 12 months. Representative data from 1 patient (A) and inverse Simpson’s measurement of diversity (n = 13) (B). (C) Cytokine production in CD8⁺ T cells from PBMCs stimulated with CD3/28 T-cell activation beads at baseline and on treatment (n = 6): TNF⁺, IL-2⁺, and interferon γ positive (IFN⁺). Dotted line indicates average cytokine percentage in 8 age-matched donors. P values from a Wilcoxon’s matched-pairs signed rank test compared with baseline. *P < .05.