Patients treated in AIM exhibit significant dysregulation of immune subsets at baseline. (A) Flow cytometric analysis of CD4⁺ and CD8⁺ T-cell subsets. P values from an unpaired Student t test with Holm-Sidak multiple corrections. (B) NK cells, CD16⁺ NK cells, γδ T cells, and CD14⁺ cells in AIM patients at baseline (n = 16) and age-matched healthy donors (HDs; n = 13). P values from a 2-tailed Mann-Whitney U test. *P < .05, **P < .01, ***P < .001.