Figure 5.
Proposed model of the pathogenesis of NPM1-mutated AML. Mutant NPM1 promotes leukemogenesis by interacting with chromatin-bound XPO1 at HOX loci to facilitate their expression (A) and binding and exporting several nuclear proteins, including tumor suppressors and transcription factors, to the cytoplasm, likely inhibiting their normal functions (B). import, importin α/β.