Iron, hemoglobin, and transferrin changes over time. Iron levels in the overall population (A) and percentage change in iron levels in TI-R and TI-NR subgroups (B). Other markers related to iron metabolism in the TI-R and TI-NR subgroups: hemoglobin (C), and total iron-binding capacity (D). For the TI-R group only, pre–TI-R is the last visit with data before the start of TI response, and week 2 is the visit 2 weeks after the pre-TI response visit; the same applies to the other post-TI response visits. (E) Forest plot of percentage change in anemia biomarkers from pre-TI response for TI-R patients at 2 weeks; 95% CI is based on the Student t test for paired samples.