Associations between molecular and cytogenetic abnormalities (with prevalence ≥10) and response. (A) The association between individual frequently mutated genes (≥10 times) and frequently observed cytogenetic abnormalities (≥10 times) and response (CR/CRi) after 3 cycles. Odds ratios are displayed on a log₁₀ scale, with lines extending to the 95% CI. Horizontal bars indicate the proportion with a mutation in the respective gene for patients with (blue) and without (red) response, with absolute numbers given for each gene. Data on molecular abnormalities were available for 140 individuals, whereas cytogenetic abnormalities were assessed in a subset of 114 individuals with identified cytogenetic abnormalities. P values are derived from Fisher’s exact test. The association between response (CR/CRi) within 3 cycles and highest variant allele frequency (VAF) per individual (B), number of mutations per individual (C), and number of mutated genes per individual (D). P values are from Wilcoxon signed-rank test.