Figure 5.
Immune microenvironment modulates FL dependence on BCL-2. (A) Mitochondrial priming with BIM peptide in FL samples. (B) Binding preferences of BH3-only proteins/ peptides with antiapoptoctic BCL-2 proteins. (C) Examples of BH3 profiles from 3 individual FL patients showing patterns of relative dependence on BCL-2 (FL13), BCL-XL (FL12), and MCL1/BFL-1 (FL14). (D) BCL-2 family protein dependence was assessed by BH3 profiling using venetoclax (VEN, n = 9), BAD (n = 13), HRK (n = 13), NOXA (n = 13), and FS2 (n = 6) in FL-FDC and FL-Mϕ cocultures. *P < .05, **P < .01.

Immune microenvironment modulates FL dependence on BCL-2. (A) Mitochondrial priming with BIM peptide in FL samples. (B) Binding preferences of BH3-only proteins/ peptides with antiapoptoctic BCL-2 proteins. (C) Examples of BH3 profiles from 3 individual FL patients showing patterns of relative dependence on BCL-2 (FL13), BCL-XL (FL12), and MCL1/BFL-1 (FL14). (D) BCL-2 family protein dependence was assessed by BH3 profiling using venetoclax (VEN, n = 9), BAD (n = 13), HRK (n = 13), NOXA (n = 13), and FS2 (n = 6) in FL-FDC and FL-Mϕ cocultures. *P < .05, **P < .01.

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