Idelalisib modulates biological pathways in FL-FDC cocultures. FL primary cells were isolated from monocultures or FL-FDC cocultures with/without idelalisib (500 nM, 48 hours) and subjected to GEP. Gene sets regulated by idelalisib were identified by GSEA using custom genes sets, C2 canonical pathways, C3 motifs, Hallmark, and C5-GO signatures. Enrichment plots (A) and heatmaps (B) of the corresponding leading edges of selected gene sets are shown.