Prediction-corrected visual predictive checks to validate the models: comparison of FX- and FII-time modeled relationships using the final covariate models with observed data from the phase 3 trials. (A-B) FX-time relationship is shown in panel A and FII-time relationship in panel B. The black circles represent observed patient data from the phase 3 trials. The blue solid and dashed lines represent the observed median, 20th, and 80th percentiles, respectively. The red solid and dashed lines indicate the corresponding percentiles from the model simulations. The pink shaded regions are the 95% confidence intervals for the simulated percentiles.