Magnitude of expansion of T cells in patients 1, 3, 4, and 5. (A) Total number of T cells carried with the CB graft of each index patient was extrapolated from 30 historical CB grafts. Median and IQR of T-cell content from the historical CB grafts were multiplied by weight of the index patient to derive approximate number of T cells transferred at the time of CBT. Total blood volume based on weight of the patient was calculated, and thus, total number of circulating T cells during expansion and magnitude of T-cell proliferation were calculated. Magnitude of T-cell expansion after 168, 192, and 216 hours for each patient is labeled in respective color. (B) Absolute cord blood CD8⁺ T-cell count in patients 3, 4, and 5 was measured daily during the early unprecedented expansion. CD8⁺ T-cell expansion is compared with median CD8⁺ T-cell count (and IQR) of control patients (n = 30) from the historical cohort. (C) Absolute cord blood CD4⁺ T-cell count in patients 3, 4, and 5 was measured daily during the early expansion. CD4⁺ T-cell expansion is compared with median CD4⁺ T-cell count (and IQR) of control patients (n = 30) from the historical cohort.