In vivo antitumor activity of NEO2734 in an AML xenograft model. (A) Antitumor activity in the AML MV-4-11 xenograft model treated with NEO2734, molibresib, or vehicle. Lines show median values per time point with the corresponding interquartile range. On the y-axis, the tumor volume is given in mm³; x-axis, days of treatment. (B) Tumor volume at the best vehicle per treatment day (day 18). (C) Body weight at the first and last day of treatment. Treatments started when tumors became visible (150 mm³). Six mice were treated in each group. The Mann-Whitney U test was used to compare groups. *P < .05, **P < .01.