Relative survival of patients with HCL compared with a matched Swiss population. Absolute survival was calculated from the start of treatment and was compared with expected survival of an age-, sex- and period-matched Swiss general population using the life-table approach. The blue line represents the expected cumulative survival of the matched normal population, the black line represents the observed cumulative survival in patients with HCL, and the hashed lines represent the 95% CI of the cumulative observed survival. Patient with HCL showed a slight statistically significant inferior OS compared with the normal population (P = .036).