Survival of breast cancer patients correlates with expression of tumor tissue EphB4 and ESA therapy. Tissue samples from a cohort of patients with breast cancer were stained for EphB4. These patients had similar demographic and tumor prognostic features. The patient subgroup with high EphB4 expression was analyzed for survival based upon patients being exposed to ESA or not. Patients with high EphB4 expression who received ESA therapy had a shorter survival than those who did not receive ESA therapy. Adapted from Pradeep et al,⁸¹  with permission.