Algorithm using serum ferritin and transferrin saturation to predict response to iron in cancer-associated anemia. Green boxes indicate benefits of IV iron therapy. Yellow boxes indicate that an iron trial may be beneficial. Red boxes indicate that iron should not be given. Patients with TSAT <20% and inflammation elevating the serum ferritin (up to 100 ng/mL) will likely respond in a manner similar to that of classic AIDA; patients with ferritin >100 ng/mL may exhibit slightly lower Hb responses. A CHr and reticulocyte count may help to determine whether to give iron in this instance. Professional illustration by Patrick Lane, ScEYEnce Studios.