Baseline factors associated with symptom and spleen response to JAKis. (A) The results of univariate (top) and multivariate (bottom) logistic regression analyses of baseline factors predictive of symptom response at 6 months according to the revised IWG-MRT/ELN²³  in 61 patients with MF treated with JAKis. (B) The results of univariate (top) and multivariate (bottom) logistic regression analyses of baseline factors predictive of spleen response at 6 months according to the revised IWG-MRT/ELN³  in 61 patients with MF treated with JAKis. Firth’s logistic regression method was used to cope with the bias of maximum likelihood estimates. BL, baseline; LCM, left costal margin; MF-RUXO time interval, time interval between myelofibrosis diagnosis and initiation of JAKis.