American Society of Hematology

Figure 5.

Both inhibiting ferroptosis and deleting hepatic Slc39a14 alleviates CCl4-induced fibrosis in Trf-LKO mice. Control, Trf-LKO, and DKO mice were treated with vehicle (oil) or CCl4, and liver sections were obtained and stained with Masson’s trichrome (A), Sirius Red (B), or 4-HNE (C); the scale bars represent 100 μm. Hepatic MDA (D) and non-heme iron (E) were measured in the indicated mice (n = 4-5 mice/group). *P < .05, **P < .01, one-way analysis of variance with Tukey’s post hoc test. n.s., not significant.

Both inhibiting ferroptosis and deleting hepatic Slc39a14 alleviates CCl₄-induced fibrosis in Trf-LKO mice. Control, Trf-LKO, and DKO mice were treated with vehicle (oil) or CCl₄, and liver sections were obtained and stained with Masson’s trichrome (A), Sirius Red (B), or 4-HNE (C); the scale bars represent 100 μm. Hepatic MDA (D) and non-heme iron (E) were measured in the indicated mice (n = 4-5 mice/group). *P < .05, **P < .01, one-way analysis of variance with Tukey’s post hoc test. n.s., not significant.

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