The combination of DEX and RUX cooperatively attenuates disease manifestations in an in vivo model of HLH. (A) Bodyweight over time relative to baseline bodyweight of naïve mice and vehicle- and drug-treated LCMV-infected mice. Statistical significance is relative to the naïve condition. (B) Survival of naïve mice and vehicle- and drug-treated LCMV-infected mice. (C) Plasma ferritin levels in naïve mice and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. (D) Hematocrit (HCT) values in naïve mice and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. (E) Platelet count in naïve mice and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. (F) Spleen weight as percentage of initial bodyweight and representative spleen images from naïve and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. (G) Number of monocytes in spleens from naïve and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. (H) Number of neutrophils in spleens from naïve and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. (I) Representative histologic images and percentage of total area staining positively for Ly6B.2 in livers from naïve and vehicle- and drug-treated LCMV-infected mice on day 9 postinfection. Statistical significance was assessed using 1-way ANOVA with Tukey’s method for multiple comparisons adjustment (A, C-I). With the exception of panels B and I, all data represent a combined analysis of 2 independent experiments. ****P < .0001; ***P < .001; **P < .01; *P < .05.