IL-2 exposure decreases the apoptotic potential of murine CD8 T cells and this apoptotic potential is restored upon RUX exposure. (A-C) Percent priming values generated from BH3 profiling of murine CD8 T cells treated ex vivo with or without 10 ng/mL of IL-2, 1 µM DEX, and/or 500 nM RUX for 16 hours in technical triplicate prior to BH3 profiling with 1 µM ABT-199 to measure BCL-2 activity (A), 10 µM WEHI-539 to measure BCL-xL activity (B), or 10 µM synthetic NOXA peptide to measure MCL-1 activity (C). Statistical significance was assessed using 1-way ANOVA with Tukey’s method for multiple comparisons adjustment. All data are representative of 3 independent experiments. ****P < .0001; ***P < .001; **P < .01; *P < .05.