American Society of Hematology

Figure 2.

$Renal pathological findings. (A-C) Pure LCDD. (A) Light microscopy (Periodic acid–Schiff staining, original magnification ×400). Section of renal cortex showing nodular glomerulosclerosis with nodular mesangial deposits (arrows) and aneurysmal dilatation of the capillary lumens (asterisks). Bar = 50 µm. (B) IF microscopy (anti-κ fluorescein isothiocyanate conjugate, original magnification ×200). Linear deposits along glomerular (asterisks) and tubular (arrows) basement membranes, and around vascular myocytes (arrowhead). Bar = 50 µm. (C) EM (original magnification ×12 000). Linear electron dense deposits predominating in the inner aspect of the GBM. Bar = 1 µm. (D-F) LCDD with CN. (D) Light microscopy (Periodic acid–Schiff staining, original magnification ×200). Section of renal cortex showing TBMs thickening (arrow) and typical fractured casts in distal tubules with giant cells and tubulorrhexis (asterisks). Note the roughly normal appearance of the glomerulus. Bar = 50 µm. (E) IF microscopy (anti-λ fluorescein isothiocyanate conjugate, original magnification ×200). Linear deposits along TBMs (arrowhead) and casts within distal tubule lumens (asterisks). (F) Enlarged multilayered TBM with electron-dense (arrows) powdery punctuate deposits predominating in the outer aspect (EM, original magnification ×15 000). Bar = 1 µm.$

Renal pathological findings. (A-C) Pure LCDD. (A) Light microscopy (Periodic acid–Schiff staining, original magnification ×400). Section of renal cortex showing nodular glomerulosclerosis with nodular mesangial deposits (arrows) and aneurysmal dilatation of the capillary lumens (asterisks). Bar = 50 µm. (B) IF microscopy (anti-κ fluorescein isothiocyanate conjugate, original magnification ×200). Linear deposits along glomerular (asterisks) and tubular (arrows) basement membranes, and around vascular myocytes (arrowhead). Bar = 50 µm. (C) EM (original magnification ×12 000). Linear electron dense deposits predominating in the inner aspect of the GBM. Bar = 1 µm. (D-F) LCDD with CN. (D) Light microscopy (Periodic acid–Schiff staining, original magnification ×200). Section of renal cortex showing TBMs thickening (arrow) and typical fractured casts in distal tubules with giant cells and tubulorrhexis (asterisks). Note the roughly normal appearance of the glomerulus. Bar = 50 µm. (E) IF microscopy (anti-λ fluorescein isothiocyanate conjugate, original magnification ×200). Linear deposits along TBMs (arrowhead) and casts within distal tubule lumens (asterisks). (F) Enlarged multilayered TBM with electron-dense (arrows) powdery punctuate deposits predominating in the outer aspect (EM, original magnification ×15 000). Bar = 1 µm.

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